What are some downsides to immortality that most don't think of?

I'll start off with one, Being upset about a breakup that happened hundreds of years ago.

Edit 1:

Heath death of the universe, Death of the sun, etc, does not count. I feel like focusing on this is an overused point.

Edit 2:

Loneliness does not count. I feel like we all know immortality means you'll miss people and lose them.

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The rest of humanity will eventually evolve into something you don't recognize and can never be part of.
- My thought. In 500M years, you would be like the slime that crawled out of the oceans to the dominant life.
- Neanderthals wanted to live forever and now we have bigfoot.

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