I have always wanted to try printing larger, using a bigger nozzle - just got around to swapping to a .6mm in my MK3S+. Printed a gift for a childhood friend. 300% size. Took just under 10 hrs. With the slicer settings on .4mm it was over 17hrs.
I also use .6 as my standard nozzle. Since the stuff I print is usually custom brackets and cases, a bigger nozzle would be even more ideal. The problem is my stock heating can't keep up with anything larger than a .6
I have the same setup and with a bigger nozzle I found it useful to use auto speed and max volumetric flow, rather than speed. I found the hotend reaches its flow capacity before speed becomes an issue.