It might make Valve unlikely to make another game and a lot of people, including myself, would be hugely disappointed but I don't think it would have any major negative effects beyond those two.
You also can't MTX a Half Life 3 game to hell and back. Years ago, I knew the next Half Life game would be VR. They've always used the Half Life games to showcase new tech or models(the Episodes). Didn't realize it would be VR Exclusive or a prequel.
At least the community has given up and is producing their own sequels and spinoffs.