Did you have to mess around with it at some point?
I've been Firefox with uBlock Origin for a couple years and haven't ever messed around with the settings other than turning it off for a few select websites. Haven't had any of the issues other people reported with youtube.
At the very beginning I had to switch from ABP to uBO. I actually used ABP specifically because I wanted to allow through some non-obtrusive ads, because I think it's morally right to let companies make a profit if they're not being overly obnoxious about it, and ABP's Acceptable Ads policy is great for that. Unfortunately ABP was slower to implement something to avoid YouTube's fuckery, so I switched to uBO. Google has shot themselves in the foot because now instead of a small number of ads getting through, none do.
At the very beginning of their crackdown I remember I had to update shit a few times to get rid of that 'no adblocker' screen but yeah...its been months now and youtube is perfectly normal.