I think about this a lot to the point where I imagine creating a game that like specifically tries to prevent it by any means necessary including just lying to the player.
I also think an anti-speedrun game could be fun possibly.
You could probably randomize the actual numbers for like soft-caps, hard-caps, scaling numbers, etc. so there's no universal scaling and relationship between the different factors of the game for people to easily post about online. Although I suppose someone might reverse engineer whatever the seed that generates the new values and then build some kinda' online build tool to ruin this.