I have always wanted to try printing larger, using a bigger nozzle - just got around to swapping to a .6mm in my MK3S+. Printed a gift for a childhood friend. 300% size. Took just under 10 hrs. With the slicer settings on .4mm it was over 17hrs.
That is a very good question. There aren't any insane overhangs, just a few tricky spots. I had print he same thing smaller, so I knew it would be okay. I think the file actually mentioned in the notes that you COULD print it without support.