There’s an npc in a Skyrim mod who wants your help to find this magic tome. When you find it they use it to turn into a woman, coming out as trans. It was super cool, I genuinely didn’t expect it.
There's a quest in the old-school MMORPG Runescape where the player has to be a woman to proceed, and if playing as a male you get given a voucher for a free gender change.
No explicit comparisons to IRL trans people, but still, it's there.
I used to play the bajeezus out of that game and forgot about that quest.
On an related note, did you know about the 2009scape project? It's a surprisingly complete open source server and single player implementation of RuneScape circa early 2009. The server is super friendly and free to play on
I didn't know about that, no. To be honest, I haven't played the game since 2007; I dropped off of it for unrelated reasons, before the changes that came later that year which were the cause of people's upset that ended up creating 07Scape.