Normal Adblockers like ublock only block advertisements and random crap. AdNauseam takes it a step further and goes on the offensive against advertisement agencies by poisoning the data they collect on you.
AdNauseum will click every single ad in the background and has ublock integrated inside to do the standard adblocking. This will make all their data on you useless.
Google has banned it from the chrome web store so you know it's working great. You can use it on both Firefox and Chromium based browsers by using the guide from the official website.
Remember to update the ublock filters once installed to bypass whatever Youtube is trying to block ads now.