I'm imagining a series finally like a weird mixture of Clue and Fallout 4 where the last episode has four possible endings and three are basically the same and they're all shown.
Todd Howard already said that they aim to be as ambiguous as possible and not canonize any of player's choices. It will probably be "yeah there was a big trouble here a couple of decades back but it's all ancient history now so who cares". And the town's leader will be some schmuck who hasn't even heard of Mr. House.
That seems the pattern, especially with comedies. I get the sense Netflix (any streaming platform really but especially newcomers Netflix and Amazon) seem to be quick to cancel a streaming show for any or no reason.