Can GRUB cause issues with USB mice occasionally?

The only Linux questions community I found appears to be locked, so I hope it's ok to ask here..

For a very long time I've had the issue that occasionally, perhaps 1 out of 40 boots, my mouse does not work once the OS starts. The mouse appears to turn on during POST/BIOS/GRUB, then it goes dark again while the OS is booting, and to make it turn back on I have to crawl under the desk, unplug it and plug it back in. 39 times out of 40 (approximately) it just goes dark briefly and turns on in time for the OS. The mouse also works just fine in UEFI.

This happens in Xubuntu, Fedora and Windows, and with two different mice from different manufacturers. I've also upgraded the motherboard twice and pretty much every component in the computer. The only thing that's always has been there is GRUB, which is why I suspect it could be involved.

It happens so rarely that I never really bothered to try to find a solution for it, but it is kinda annoying when it happens.