My personal favourites are moody third-person shooter El Paso, Elsewhere, in which you battle addiction and try to kill your vampire ex-girlfriend to stop the end of the world, and Space Warlord Organ Trading Simulator, a simulator game where you, well, trade organs on the intergalactic stock market. Shoutout also to the dog JPEGs manning the airport in An Airport for Aliens Currently Run by Dogs.
I’ve seen praise for these, I should finally play them!