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Can Wine / Proton / any translation layer run games from external drives?

I'm currently using Windows 10, but I'd like to switch to linux.

I know it's crazy and weird, but I currently have 3 SSDs and 2 HDDs. One M.2. SSD is used for the OS (Windows 10 in this case) and the other two SSDs are used for games (I currently have about 1.7TB of games on my PC, spread across two SSDs of 1TB each). Besides that, I have one HDD used for general files and the other one for emulated games. (In my case, mainly my totally legal copies of various games from the high seas and a ton of Wii games for the dolphin emulator).

If I were to switch to Linux, would it be possible to keep storing and running the games from other drives that aren't the C drive? And would it be possible to keep my emulation games (mainly the Wii games) on my separate HDD?

Besides that, is it possible to run cracked totally legally acquired games but just from a .exe file?

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