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What happens if we put patches in the fridge if they say not to?

So today we finally got around to reading the instructions for some of our patches (Estradot) and realised they say not to put them in the fridge (or freezer but we wouldn't put patches in the freezer anyway). We took them out but they have been in there for months.

Are they ruined or less effective?

We started doing it because our other patches (Evorel) denatured once a while ago, and wanted to avoid the same fate with these ones since it's been a hot summer and have nowhere really cool to store them since we are on the top floor of a building and thus it gets very hot up here, even in our drawers.

So we are wondering what exactly is the problem with them being in the fridge and are they ineffective now or will they be okay now that they're in the a drawer and hopefully stay cool for the rest of the month?

We have left our other patches (Evorel) in the fridge as they don't say not to.

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