As a total beginner, it's not really clear to me what's meant here.
I read printing some things are better to print at an angle, like boxes, for additional strength.
Is that what's meant here?
This model is almost entirely overhangs with small gaps between them, making support removal a pain. This way uses less filament and makes for better quality
This particular model would have lots of troublesome bridging if printed vertically, and would need supports along the entire length if printed horizontally.
In Orca slicer, if you use tree supports and hybrid, an option appears (advanced must be enabled) for something like "Essential supports only". It is so much better than spending all that time adding or blocking supports.