Same with 'compatibility telemetry runner' after every update I have to disable it and delete the .exe from system32. None of the permanently disable tricks work. Plus I always have to run "oo shutup" to disable the other privacy stuff. I wish I could switch to another is, but most of my software is windows only.
For regular gaming experiences, WINE and Proton are brilliant. For some .NET stuff it's still lacking. On WINE, MusicBee for example lacks proper CJK font redirection and dragging the tabs on it causes MusicBee to throw errors. You might also run into issues gaming if you have certain setups + controllers too.
.NET runs natively on Linux now. so newer apps should work fine unless they're using Windows-specific APIs. For the legacy .NET Framework 4.x, they should work in Mono.
They ought to be. You might have to change ownership of the file to some other local user (and disable permission inheritance for that file so admin can't touch it), but I bet this would work for most use cases except like a system restore.