Yeah, they're partly genetic but you can risk it. I have a couple of friends who have had their third or fourth stone and I've never felt so much as a slight discomfort on my kidneys. It makes me wonder wtf they're doing to themselves but I'm not one to judge.
Ibuprofen is mostly processed by your liver as well. Acetaminophen uses a bit of both.
This appears to occur predominantly systemically in the liver [1,10], but may occur pre-systemically in the gut as well [11]. Ibuprofen is almost completely metabolized, with little to no unchanged drug found in the urine [1,9,12].
Tylenol (acetaminophen) is almost completely broken down by the liver. During this process, a toxic chemical forms. Normally, the liver makes it non-toxic. But if you take too much Tylenol, the liver can't properly process it all. The toxic chemical can then build up and poison liver cells.
That was definitely the cause of my kidney stone, because I don't take OTC pain meds frequently, but if you do have ways to avoid kidney stones, avoid kidney stones. They are no fun.
Weird, because I can feel the Aspirin when I take it. It makes me feel ever so slightly numb all over and gummy at my core in a strange way. Kind of similar to when I eat a lot of sugar and it feels like I have syrup for blood and it leaves me lethargic.
Aspirin is a weird drug. Stick to ibuprofen or even just acetaminophen if you have stomach issues. Naproxen Sodium, Ibuprofen and Aspirin all irritate the stomach lining, and aspirin adds a risk of bleeding since it's also a blood thinner.