Besides the one super-obvious (uBlockOrigin), my favorite single one would be Tab Center Reborn, which together with the styling from Firefox Vertical Tabs pretty accurate recreates the superb vertical tabs of MS Edge.
And on a desktop screen, I can't imagine going back to horizontal tabs that waste the previous vertical space I got.
Tried that, I thought it was cumbersome and a solution desperately looking for a problem, tbh. I never once in my life had the thought that my tabs need to be in a multi-tier structure. I'm not someone to collect thousands of tabs though.
I should also add that your second part makes no sense: Chrome doesn't have the vertical tabs Edge has and that this setup recreates.
I find it great as it groups your thought processes. You Google something and it opens a group for that, then you read something in one of the search result tabs and need to go to some links there/Google more stuff - that's now grouped under it so you can easily find things for that thought track. Once you are done, you can close all the tabs in one go.
As far as I'm aware you can't nest groups in edge? I'm trying now and can't even reliably create a group and it scrolls randomly when trying to move tabs around.
That final part is my point - as far as I'm aware the other browsers have nothing as powerful as this. May need to check if there is anything new though.