I just discovered something that VLC REALLY didn't like to play. A 4K50fps JPEG2000 YUV444 12bit lossless ~48 GB video that was only 1 minute long.
To be fair the bitrate of the video is insane at ~5700 Mbit/s. The bitrate is so insane that you should really consider using an NVME drive for playback.
MPC-HC could kinda play it but only with extreme stutter and lag. My CPU (Ryzen 9 5900x) was completely maxed out.
I think you need hardware acceleration for a video like this.
There are people who like VLC, but for me personally, MPV has a much cleaner interface, better configuration options, and when it comes to streaming video, MPV absolutely destroys VLC (especially when changing playback speed while the video is playing -- VLC has the audio cut out for several seconds and MPV doesn't, and that's to say nothing of the MPEG glitches)
I actually found a file format that VLC won't play, .MJP, yanked off of our network's security camera system. It requires the security company's proprietary video player.