That’s a great point! You’re definitely right. I’m seeing somewhere between 10-30% depending on patient population.
That being said, since we are naturally releasing .5mg, another .5mg is already double the normal concentration.
Another major point of consideration though would be formulation, as that is going to have a large effect on the half life of the dose in your system. Even if bioavailability is around physiological concentration at 5mg, the duration of the exposure being much longer than the time it takes for natural release would still have negative impact.
All this being said, definitely never a reason to go above 5mg
Please do! Research has shown that as little as 20 minutes of light therapy in the morning can have positive effects
Hey, I commented elsewhere on this post and I wanted to let you know that the reason it doesn’t help you is likely because all melatonin supplements are way too strong!! Our body is releasing .3-.5mg of melatonin during the evening, and over the counter melatonin ranges from 5mg-20(!!)mg per pill.
As you can see, this is WAY too much for our body, and it saturates every melatonin receptor in the brain resulting in over signaling of these pathways and a tolerance to melatonin. People who consistently take it each night can really mess up the sleep related pathways in the brain, and the desensitization means that the naturally released melatonin is not even close to creating the proper response in the brain.
It can be difficult to find in some places, but if you’d like to use it there are 1mg supplements out there that I would recommend! :)
Absolutely! Additionally, morning sun is another great way to regulate your circadian clock and let your body start its internal timer for melatonin release.
In the winter, I use a light box for seasonal affective disorder, and in addition to feeling much more energized, I find it helps me get more consistent sleep!
You’re on the right track, but funnily enough you got it switched around!
Research shows that melatonin binding leads to downstream release of adenosine, so if caffeine is blocking its binding action sleep is not on the way!
Here’s the paper I am referencing: https://doi.org/10.1016%2Fj.neuron.2015.02.016
“We find that melatonin promotes sleep downstream of the circadian clock as it is not required to initiate or maintain circadian rhythms. Additionally, we provide evidence that melatonin may induce sleep in part by promoting adenosine signaling, thus potentially linking circadian and homeostatic control of sleep”
That’s great! I really do think 1-1.5mg is the upper limit anyone should use, although it’s still higher than free melatonin concentration in your brain it’s a much more reasonable dose in comparison.
And I think most people who don’t understand melatonin go straight for the 20mg, so we’re probably talking 60+.
It really blows my mind that in this day and age there are no regulations or at the very least warnings or guidelines regarding melatonin supplements.
The gap in FDA policy for prescription drugs vs supplements is vast. Supplements have very few regulations and restrictions that create a lot of potential issues for the uninformed consumer.
0x0 is correct. If it’s a prescribed medication then my comment is not relevant! I am referring to over the counter supplements
FYI, every melatonin supplement is way too high of a dose and is completely saturating your melatonin receptors, leading to tolerance and dependency.
Your body is not producing more than .5mg of melatonin naturally, so taking a 5mg supplement is far too much. And they sell 15-20mg too. If you can find 1mg that’s best; but what’s even better in the long run is not using it!
Won’t someone think of the pollinators?!
Wait…. Uhh… won’t someone think of the students??
Wait.. hmm… well, won’t someone think of the administration I guess???
While ibuprofen and acetaminophen are both NSAIDs, acetaminophen is more effective at fever reduction and ibuprofen is more effective for inflammation
A few months ago I requested the option to mark as read by scrolling through your feed as I saw another Lemmy app added that feature. I got a reply that they would try their best but it seemed like it would be a difficult task.
Well I’ve just noticed that this feature is now an option! I may be late to the party since I don’t know when it got released, but how cool is that??
I’ve been very impressed with the development and responsiveness about requests, and this sealed the deal in making me a Memmy user for life!
This is hilarious. They obviously didn’t realize their target audience was drivers who don’t know how to handle a muscle car 😂
Why would a union agree to a pay raise that only benefits 1/5 to 1/4 of the people it’s representing? Everyone deserves a livable wage, not 20% of employees.
It’s probably just misinformation/disinformation
The creator is some kind of right wing whacko on twitter now I believe
But profits are up 5%!
“I’m gonna play both sides, that way I’ll always end up on top”
Decided to make a thread for this since I didn’t see one posted. Team USA played Team Puerto Rico in their first FIBA game of the year and won convincingly, 117-74.
A few growing pains since these guys have only been together for a couple days, but they looked amazing in transition as that was an emphasis from Coach Kerr.
Jaren Jackson Jr looked dominant on both ends of the floor with 12pts/7rebs/2blocks.
Anthony Edwards may have been the most impactful player with 15pts/2rebs/4asts along with a handful of steals as well as a blocked shot! (Box score lists him with 4 steals no block, but if you watched the game one of those steals was a blocked 3 pointer)
The Hoop Collective podcast yesterday mentioned that Ant would be a player to watch and that he has the potential to step up and lead this team, and it looks promising so far! His defensive effort was great to watch and he had some nice flashy passes.
Also want to shoutout Jalen Brunson who had 11pts and 12rebs, one of the smallest players on the court and dominated the glass.
USA Basketball link Box Score: https://www.usab.com/gamecast?id=1646
Summary article here: https://www.nba.com/news/team-usa-exhibition-puerto-rico
Me and my buddies all got todays player on the first try and it was really funny. Also have been enjoying immaculate grid but that game is way harder
I’m sure people have seen posts criticizing this feature on garmin communities in the past, but I just wanted to share my personal experience. Over the past 3 months I have really been putting effort into my exercise and fitness level, I do some sort of workout 5 days a week whether that be a bike ride, basketball cardio, or lifting weights. I can feel my body getting in much better shape and see the results in my physique, and notice my stamina and energy levels improving.
And yet, garmin VO2max seems to think I’m regressing! I know there are a lot of variables like temperature, elevation, whether I did a workout already that day etc but it is SO frustrating to see that my number did not move for 2 months and then has dropped twice in the past month, meanwhile I’m in the best shape I’ve been in since before the pandemic.
I know it’s just a silly number and isn’t the whole story, it isn’t always accurate etc. but it’s still so annoying to see. I went for a 3 mile walk today and I felt amazing, it was very warm out and the trail had a lot of hills so I know for a fact that played into the measurement, but garmin says I’ve dropped 2 points since I started working out and that’s just so dumb.
Anyways, rant over, thanks for reading if you did.
TLDR: Garmin VO2max is useless unless you’re training on a completely flat surface on a perfect weather day that isn’t too hot. Don’t let the stupid number discourage you, focus on the workouts and how you feel, because I feel amazing!
I just saw the voyager app is implementing this, can we get it on Memmy?
Hello all. I train on a stationary bike as well as a road bike, but have been doing more stationary lately. I’ve read a lot of conflicting opinions on heart rate training zones and wanted to get some input. I’m still somewhat new to bike exercising.
How often do you interval train, and how long is your workout?
Right now I do a zone 4 session about once a week, and do 5 minute intervals with 5 minute “rest” periods, so my total ends up being around 15 minutes in zone 4 and 15 minutes in zone 2.
Just wondering how other people are doing their workouts.
Any feedback, opinions, or input appreciated!
Figured I would make a general free agency post for reactions and discussions of news. Feel free to post FA signings in the comments or just give your thoughts on things so far!