If you have some spare cash you can look at IODD or Zalman (white label iodd) devices. USB disk drives that also emulate an optical disk drive and mount ISOs.

I bought a Zalman back over a decade ago, still have and use it to this day. Used the daily in at data centres. Bees knees. Looking at the IODD devices now for the USBC port, but the Zalman is still working flawlessly.

I am away on vacation and may not check back regularly, sorry in advance.

Is this only on LiveUSB? Have you installed to the SSD with acpi on and checked if it boots correctly?

If it is just the liveUSB it sounds like when you have acpi on it power cycles/changes the driver or something with the usb ports and causes the live USB to disappear while trying to boot from it.

Are you also booting UEFI or Legacy? That can change some of the answers.