I'm up to 92 so far. A mix of non English, furry and hentai porn, and a few I just don't see the point of. I've got 6 or 7 users to, mostly bots that repost reddit content, and the piped link bot.
What? Why are you blocking communities so much? Just go through the list of communities and subscribe to what appeals you you then just browse subscriptions.
Not speaking for OP, but I do it because if you block communities they don't show up when you browse by "all". That's my preferred way to find new stuff (even if it's meme heavy). I like that it's as easy to hide communities I'm not interested in as it is to subscribe to new communities. It's a great feature.