Engineers have mitigated an issue with Voyager 1’s thrusters, enabling the mission to stay in touch with mission controllers on Earth and send back unique data.
The voyager probes only got as far as they did because of their trajectory that got some massive (and rare) slingshots, it will take ages for the new horizons probe to get anywhere near as far.
We could probably spam missions to some other planets, who will pay for it though? We are not at the stage where an 'out of the box's mission can do that I think?
Space is big enough that even if we tried to “pollute” it we could not. We would need Von Neumann self replicating probes to even stand a chance. But even then if we are talking intergalactic we wouldn’t register.