I really think that the ''density'' of BG3 is it's biggest drawback. Don't get me wrong, the game is great, but it's so daunting it's also kind of a chore. It's barely playable if you only have 1-2 hours every other day to play because that's just not enough time to do any real progress on a quest. I honestly wouldn't be able to enjoy it if I wasn't on holiday.
I think most drawbacks of the game are also present in D&D:
-Combat gets boring and same-y very quickly
-the time commitment
-when trying to wrap up all the stories, the game becomes "a chore to finish" and not "a game to enjoy"
That being said, I still liked the first two acts in BG3. If Honormode wasn't a thing, I wouldn't've finished.
I haven't been able to play it entirely blind, which is a flaw, but it has led me to view this gameplay more as a form of authorship. You save scum and you try again because that's not the story you're trying to tell. I don't save scum games that are less storylike, because the game is traditionally the gameplay. With tabletop RPGs, the story is the game. This is an interesting middle ground.