Instead of ‘Dungeons and Dragons’ you’ve been invited to play ‘Truckstops and Tweakers’. What’s it like?

"Roll d20+resistance to avoid herpes from the lot lizard"
"The party wakes up to find all of their CB radio equipment was stolen in the night by rogue fentanyl zombies"
"Dispatch has decided to put you on a quest down I-20 westbound to pick up cargo. Also I-20 has a DUI related accident that spans all lanes and won't be cleared for another 4 hours."
"Roll strength to hurl the piss jug"
"The man on the radio has insinuated that your mother has sex with cats how do you respond?"

Well after eating the truck stop egg salad sandwich I become very healthy, agile and intelligent. My quest would be to recruit other people into my flock and to be blessed by my health and beauty.
- You ever wonder what makes special sauce so special? Yo...

Every 30 minutes you have to make a perception check and then either a persuasion check or evasion check as the crack head keeps asking for money and trying to stab everyone with a broken rusty pipe.

That sounds like d20 modern, with a whole bunch of tweaked house rules
- Always liked the idea of using the tabletop framework as a template, if only to make it accessible to a broader audience. Like, if high fantasy strikes you as low reality, or following dusty old campaign books just isn’t your bag, you can enjoy all the social creativity of tabletop games in any story setting if you’re willing to roll your own everything. World building becomes more of a group activity, so you might spend a lot of time setting things up, but then everyone can take it as seriously as they wish without feeling out of the loop.