There's a chance it sticks around longer than most other shows. It's the first animated show in the US to be (at some points in its life) the biggest show on television. And early seasons definitely influenced a whole generation of sitcoms. It's impossible to tell though, as history teaches us there's really very little rhyme or reason things survive as historical touchstones, at least not enough for people living in the era to predict it.
It's also run longer than any other fictitious show in television history, other than possibly Dr. Who. Dr. Who certainly beats The Simpsons in real time span, but for total seasons, Dr. Who only has 26, while The Simpsons seems to reign supreme at 35 seasons.
I can only think of a few other shows that outlast The Simpsons, and every single one is a talk show, late night talk show, sketch comedy show, or a game show. None of these fall into the category of fiction, and all but one of these categories are entirely period based topical shows, and it could be argued that the fourth is also a period based topical show.
Well, Lisa is more likely. Homer will just be cheering her on from the sidelines. After all she did take over for/from President Trump, not sure if they specified that it was his second term or not ....