Researchers from Pritzker Molecular Engineering, under the guidance of Prof. Jeffrey Hubbell, demonstrated that their compound can eliminate the autoimmune response linked to multiple sclerosis. Researchers at the University of Chicago's Pritzker School of Molecular Engineering (PME) have developed
When this was posted before someone who followed it fairly closely and others like it, updated the thread with info because the article was behind current info. They had already stopped the trials for MS because it wasn't working. So they began to just focus on one other, the Crohn's, I believe. Figuring if they got one to work, they could go back to the others and get them on the right track.
I have MS, and while this is a new approach, there have been so many articles about treatments that end up going nowhere after the first excitement. So it is still very early to get hopes up.
Hope can be a dangerous thing. Hope can drive a man insane, as Red said.
Is it possible that other person was just full of shit?
Here was an update posted on Sept 12th, 2023 from the company behind the trials regarding the MS trials:
Anokion has completed patient enrollment early in the second and final MAD cohort of its MoveS-it (Multiple Sclerosis Study of ANK-700 to Assess Safety and Immune Tolerance) clinical trial to evaluate ANK-700 for the treatment of patients with multiple sclerosis. MoveS-it is a randomized, double-blind, placebo-controlled Phase 1 study evaluating ANK-700 for the treatment of patients with relapsing remitting multiple sclerosis (RRMS). MS is a demyelinating disease of the CNS, in which the immune system attacks the myelin sheath in the brain and spinal cord. RRMS is the most common type of MS, characterized by recurring episodes of new or worsening symptoms. Anokion has designed ANK-700 to re-educate the immune system by inducing antigen-specific tolerance to myelin-based autoantigens to reduce neuroinflammation in the brain and spinal cord.
Safety data from both the SAD and MAD cohorts supports that ANK-700 is safe and well-tolerated at all dose levels tested through the dose escalation period. Further, preliminary biomarker data from the MAD cohorts displays trends in antigen-specific immune tolerance and evidence of bystander suppression to related myelin antigens, which is critical to treating complex autoimmune diseases like MS.
The study will continue with a 12-month safety follow-up expected to complete in the first half of 2024. Anokion anticipates reporting full results from its MoveS-it clinical trial in the second half of 2024.
This says that the single dose (SAD) phase 1 trial which began in 2020 was completed and they moved on to the second multiple ascending dose trial (MAD) for MS which completed enrollment and expect results in 2024. And that the preliminary data from the first MAD trial indicates therapeutic response.
And the press release talks about how they've moved on to a phase 2 trial for its use for celiacs (the initial trial use case). And then on Oct 12th they announced they will be presenting data from their phase 1 for celiacs at a conference.
A week after the announcement quoted above they released the news about their peer reviewed paper mentioning the early success in both (what likely inspired OP's article), saying:
We have now observed our approach play out in the clinic with early data from our lead programs in celiac disease and multiple sclerosis, KAN-101 and ANK-700, that demonstrated antigen-specific tolerance, bystander suppression, and an impact on disease-specific biomarkers.
None of this looks like a company that has a failing drug on their hands. And there's no indication of the MS trial being ended early - the only thing that happened early was completing enrollment early.
Being too ready to give up on hope is its own kind of insanity.
So, if I understand this right, a more accurate title would be "Research into vaccines against autoimmune diseases continues, new data indicate that a change of focus might be needed"
Don't get me wrong, this would be fantastic if it's true. But I'm sceptical. It feels like all those articles about a cure for cancer that then never go anywhere.
Every science article is just a comment section disapproving the article. That's why I stay away from these science communities, it's all clickbait and lies
Yeah Reddit always had that problem, I think it's here too - top rated comment is someone saying it won't work and the article is wrong, everyone just accepts it without question.
I still see people using battery breakthrough stories as an example of stuff that never comes too market despite most of them being in the very phone the person is using.
I genuinely think a lot of them are just people who hate science and engineering so don't want people to be interested in it
Looks at that.... The one thing good about reddit was the /r/science sub, it was always full of moderator deleted comments that were off topic, factually incorrect, etc. posted articles actually were scientific reports and not clickbait crap lik this
Easy hack. Get a bunch of more affordable health care services during the year until you reach your out-of-pocket max, then go in and get your 3 million worth of shots all on the insurance company's dime with zero extra cost to you.
The creators call it an inverse vaccine. A vaccine causes the immune system to recognize a compound to attack. This treatment causes the immune system to ignore a compound it had previously recognized. So they are specifically saying it's not a vaccine (and OP is misrepresenting them), even though that word is in the phrase, something roughly like antivenom is not a venom.
It is not a cure for the reasons others in this thread have stated. It doesn't repair damage already done, it only prevents the disease from advancing. That's still a huge deal, though.
But when it comes to type 1 diabetes the cause is the body destroying beta cells in the pancreas and everything else is a symptom of that. If you can make the body "forget" killing beta cells (like the article states the anti-vaccine would, or rather teach the body to not kill) then it would make sense for the body to recover and repair the damage done.
So skimming through the link, it's a vaccine because it's still triggering a specific body response to fight the illness as opposed to directly attacking the illness itself? Is that a reasonable layman's summary of why it's called a vaccine?
(Old x'er here, Vaccines have been preventative for as long as I've ever known, that's the reason for the question.)
The amount of science research funded over COVID that allowed for the rapid development and testing of mRNA technology has created a boon for centuries to come. COVID may well be responsible for the death of autoimmune diseases.
Hi there! Looks like you linked to a Lemmy community using a URL instead of its name, which doesn't work well for people on different instances. Try fixing it like this: !crohnsandcolitis@lemmy.world
I would give anything to be rid of this disease. I haven't slept a full night since 1996. And the pain... And it always seems like nobody understands. 'Oh him? He just poops a lot, ignore the doom and gloom.'
If you're selling insulin and I cure/prevent diabetes with a single treatment t, you no longer have a market and I have literally every human being on the planet.
Medical science is an arms race, and cures are nukes. You make the best cure, you win. Full stop.
Ehhh, maybe? If I'm reading the article right (and I haven't yet gone digging past the article to the source itself because that takes more time than I currently have), it's targeting t cells only. Rejection involves more than just t cells though.
It might be at least partially effective, I'm not trained in the field to be able to predict that much, just basing what I'm saying off of past reading and general information.
I'm not confident in this, though. It's pretty damn far beyond the level of actual training I've had. I can say confidently that the basic techniques they're talking about should be applicable to more than just autoimmune disorders, just not the degree of efficacy.
There's just so many more cells involved in something like hyperacute and acute rejection that it's likely to be something that would have to be more complicated than the already complicated technique they're working on.
I would say that, if this proves to work in actual humans safely and effectively, that the immune related cancers would be the more probable beneficiaries of the method.
See, most of the autoimmune stuff is a "false positive" the body at some point got fooled by some kind of external agent, that happened to match some part of the body. So, if you wipe out the "memory" of that false positive, the body stops attacking itself.
The cancers that are immune related should respond in a similar way. You'd still have the malignant cells, but it should stop new ones from going crazy, and the usual methods of killing off the existing malignant cells should effectively "cure" the person with drastically reduced chances of relapse.
But with transplants, there's no false positive. There actually are foreign cells in the body, being constantly exposed to immune cells. There's also usually more than one kind of cell, so the method they're using probably would need multiple efforts to work at all, and would likely need to be administered regularly. I'm fairly confident that the method could reduce severity of rejection, but that's still only fairly lol. But, (disclaimer again), the method should work in either a single or small number of treatments for autoimmune diseases.
I hope like hell this gets into human trials fast. I have a personal stake in it (hence all the reading lol) and what this thing can't do is undo the damage already done. The person being treated is still going to have whatever degree of disability the disease already caused, so the sooner people can start the treatment, the better off they are.
Most of the diseases explicitly listed as targets for this treatment are fucking brutal. Just one year with MS, as an example, can take someone from healthy and active to being half blind, or unable to walk unaided, or any number of other issues. MS already takes time to diagnose, so pretty much everyone that has it has some degree of disability by the time they start existing treatments. And the existing treatments, as incredible as they are, don't fully prevent new damage occurring. Nor do all of them work at full efficacy for everyone. You can end up having to try multiple treatments to find the right one for your immune system.
So, most MS patients have a serious amount of time before their disease even gets slowed. My wife, from diagnosis to first partially effective treatment, went almost a year, and lost so damn much from that time plus the effects from before diagnosis. You're talking someone that was modeling and a jogger being unable to walk down a hallway until over a year of physical therapy, and still can't handle long walks.
And she didn't even lose as much as some people do. She also deals with what's called relapsing/remitting MS (RRMS) which takes breaks between attacks. People with primary progressive MS (PPMS) can lose function faster and more severely. It's a fucking terrifying disease.
This is starting to go very long and tangential, so I'll stop after this bit.
I hope like hell it will work for not only the listed diseases, but rejection too. Gods, the lives it could make better if it can do all of that would change the world, along with the individual lives. It would be the scientific equivalent of a miracle cure.
I remember seeing something on reddit about this earlier this year iirc. Definitely exciting and I certainly hope there is credence to this. Would love to see auto immune disorders go by the wayside in the next couple decades. Once they fix all the real bad ones I hope they make one for vitiligo, I'm tired of 70 spf sunblock and weird looking tans.
Yeah, but both are "the immune system attacking something it shouldn't", so I wonder if the same mechanism can desensitize it to allergens.
The article mentioned trails for celiac which although it says is autoimmune, at least involves a foreign substance
i like how people complain because they weren't properly spoon fed curated articles selected specifically for them by someone who gaf. 1) be kind - is a reminder to myself