What is our guaranteed tear jerker movie or scene?

The first minutes of Up.
- Man, worst second date ever. Had no idea what I was walking into in that theater
  
  I took the kids to see some fun animation movie. Got totalled in the first few minutes.
  "Some dust got in my eye. Here, you can eat my popcorn."
- Why is anything else listed here?
  
  Because the question isn’t, “the most.” And even then, that’s subjective.

A few episodes of Futurama. You can guess which ones.
- That's one for sure.
  Edit: but not the biggest culprit for me
  
  This one gets easier when you remember that they retconned it later.
- The one where Nixon's reelected hits too close to home.

Been a while but probably the opening sequence of Up

The scene in Interstellar when he returns from the time dilation to watch like 40 years of updates he missed from his kids.

"I have been, and always shall be, your friend."
-Spock, Star Trek II: The Wrath of Khan

The last 15 minutes of "The Return of The King," starting with, "My friends... You bow to no one."
Every. Damn. Time.
- Yes. Bawling like a baby!
- Seen this more times than I can count, and tears every time.

Grave of the fireflies... Sometimes the trailer is already enough... F*** can't even rewatch the thing...
- I watched it once, and cried for two hours. Not going through that again!
  
  I always recommend it... But also with the warning: You will only be able to watch it once!
- I watched it once and didn't cry but I must've been dissociated AF or something because I don't remember any of it.
  
  The breaking point for me is when his sister is chewing on the bottons.
- I’ve never seen the movie. Reading the summary was enough to mess me up. I don’t think I’ll ever be able to watch it.

The original Fresh Prince when Will is desperately trying to convince himself he doesn't need his dad. Every time.
- It's funny that for having such a full career I still think Fresh Prince was an absolute masterpiece and unequaled by anything else Will Smith did. (Second place was probably the original Men in Black).
- Link for the uninitiated.
  "How come he don't want me, man?" And the way Phil grabs him for the hug 😭💔

What dreams may come, 1998 movie with Robin Williams.
- That's a good one, another good Robin Williams is Patch Adams.

Ending of the Sixth Sense.
"Grandma says you asked her a question. She says to tell you the answer is 'every day', what was the question, momma?"
"Did I make you proud?"

"where do you think we are?"
The context is what makes this powerful. The buildup, the misdirection, the reveal.
This was Scrubs at its best. McGinley should have won an Emmy right there.

Miguel from Coco singning "Remember me" with Coco.
- Omg I held it together so well* during Coco until one of the final scenes when Hector picks up Coco and I absolutely lost it.
  *I cry at everything so "well" for me is probably not well for anyone else

Spock: “I have been and always shall be your friend” [dies]
Kirk: “No….”

Buffy The Vampire Slayer, “The Body”.
Mom? Mom! Mommy?
- Most are giving joke answers.
  This one hits hard.

Into the wild when he discovers that human existence isn't meant to be lived in isolation and then dies a few days later in total isolation.
The end of Saving Private Ryan always gets me as well.

All those crying Pokemon in the first film when Ash is turned into stone.
- Pikachu crying gets me every time :')
- They're just weeping because he's recently discovered titties are a thing he can potentially enjoy, and Pokemon're no longer very interesting to him, as a result. 🥹

Buffy the TV show, when she discovers her mother's dead body.
"Mom? MOM! ... Mommy?" Tears
- She looked so lost, it hit me like a gut punch
- Ugh for sure. I didn’t even realize it until it was called out, but that episode also has no background music. It’s a subtle change but it makes everything so much more real and unnerving. Just thinking about that episode is making me cry now!

Birdman (with Michael Keaton) - nothing in the actual movie but the absolute soul crushing sadness when I realized that they weren't making a Harvey Birdman Attorney at Law movie.
- You want a tearjerking Michael Keaton movie, watch My Life. Hydrate afterwards, plenty of electrolytes, you're welcome.

Opening for “Up” not in the top comments?

I cry quite easily, so a small sample of films that have made my eyes misty are:
The Remarkable Life of Ibelin
Bridge to Terabithia
A Monster Calls
- +1 for bridge to terabithia. That movie still chokes me up.
  
  I was older and had never read the book. I was not prepared for that turn.

A lot of seens in Logan with Professor X. His mental decline was a gut punch because I was watching my grandfather go through the same thing at the same time. His portrayal was spot on.
Happy with Stark's daughter on the porch talking about cheeseburgers. Such a small moment, but so genuine feeling.

"A toast to my big brother George, the richest man in town."
Alternatively:
"You are who you choose to be."
"Superman."

This scene from Interstellar. I'm thoroughly convinced that it is impossible to get through this movie without getting teary-eyed at least once.
- Can’t watch it for some reason. Is it the scene where he sees his kids’ videos after losing time on the water planet?
  
  It's the one that happens later on in the movie towards the end, though the first scene you mentioned is definitely one that still gets me teary eyed!
- Murrrrphhh!

Maes Hughes' big action moment in Full Metal Alchemist - either version.
Alternatively, the scene this music https://youtu.be/EL7e5XrzanA goes to (Ep 5 of Cowboy Bebop) - far more of a tear jerker for me than the final episode.

Oh the scene/secquence? From Tim Burton's "Big Fish" when he gets the dad back in the water. That was so wholesome but so sad at the same time.
- Came here for this. When he’s walking with his dad past all the people from his life smiling and saying goodbye, I always get serious feels. Had a little tremor just typing that out!

"little soldier boy" episode from Avatar: the last Airbender. Every time.
- Leaves from the vine…
  
  The thing is by the time I decide to watch the series again, I always forget exactly where this episode is. Tears every time.

S1E3 of Last of Us - "Long, Long Time." Happy and sad tears galore.
- The whole season was great (more than half of the guest actor and actress nominations came from the series), but that may have been the finest hour in television history.
  I don't want to spoil the episode for anyone, but I'll point out that my ultra-right parents changed their stance on a major social issue after watching it because it was just so beautiful.

Another one is the movie 'The Fountain' which is played excellently by Hugh Jackman.

General Waverly walks out in uniform to find his old unit waiting for him. (“White Christmas”)

"Superman!"
- You stay, I go. No Following.

Star Trek DS9’s “The Visitor”
- "Duet" gets me too
- This one got me.

I found the entire concept, but especially the "happy ending" of Paulie to be tragic and extremely depressing to me.
My mother loved Beaches and Steel Magnolias but they always ruined my day. Then my mother died of cancer and they crossed into the unwatchable list.

The sequence at the end of the Six Feet Under finale set to Sia's Breathe Me absolutely gutted 2005 me.
- Not a tear jerker for me, but still easily one of the all time best endings for a show. Wonderful montage set to a perfect and beautiful song. After it aired, the next day, people at work were asking me how it ended but not wanting any spoilers. I just told them:

The last scene of the last episode of Six Feet Under.

Cinema Paradiso. Wonderful Italian film about a boy’s relationship with an elder in the town as he mentally escapes war torn Sicily. Just wholesome and hits hard. It’s a beautiful story and the soundtrack by Ennio Morricone, ohhhh so good.
- animale!

Les Mis
for example: https://m.youtube.com/watch?v=ulJXiB5i_q0
The ending of that Scrubs episode with Brendan Fraser https://m.youtube.com/watch?v=e__1KU7lg-4
The ending of Jurassic Bark https://m.youtube.com/watch?v=0WBbKSFhw9A
Watching the music video for My Heart Will Go On
The ending of this Cold Case episode https://m.youtube.com/watch?v=jMc_RyGBjBE
The ending of Pan's Labyrinth
The music video for Hozier's Take Me To Church
The liberation of a concentration camp in Band Of Brothers

I've been watching Shrinking and it has a lot of those moments
- Yeah, I don't know which is more effective at catching me off-guard with shit I've not thought about in decades: Shrinking or The Bear. 😅

The opening scene of Hackers (1995). Poor kid can't use a touch tone telephone or computer until his 18th birthday.
That's like taking away Mozart's piano.

First season of After Life by Ricky Gervais.
The scene after where Gervais' character realizes fully what he has done, especially to himself long term, is soul crushing. The i did the right thing, but for all of the right and wrong reasons look on his face is haunting. I think it is the 2nd episode.
A lot of the episodes open with him watching his wife telling him to enjoy life. Her sitting on the hospital bed, on her final days because of cancer.
- I hated gervais before this, i found his comedy delivery and style very grating but after watching this shoe and getting kicked in the guts every couple episodes i gave him another shot and dont mind him so much now. Show is a 10/10 if you want to sob silently with your partner.
  
  He can be eyerollingly obnoxious. And he is becoming more and more out of touch.
  He tends to have a heart and in the right place. His XFM auditions were the greatest proof of this.

So I don't get to the cinema much, but I got to see The Muppets when it came out (over a decade ago, good grief), and Kermit singing Pictures In My Head totally broke me.
Dunno whether it will work for anyone else, but like many of a certain age, I grew up with the original Muppet Show on TV and it hit too damn hard.

Inside Out
- Feeling brave, tried rewatching it and got to the scene with Bingbong and I had to turn that shit right off because I couldn't stop crying. I cry at a lot of things but few movies have ever made me cry as hard as this one.

The Iron Giant

The episode "The Sign" of Bluey, the end.
- From Bandit getting that phonecall onwards is all tears.
- Sleepytime. What a gut-punch
- For me, it's "Grandad"

John Q
Up

Toy Story 4. The scene where Woody says goodbye to the rest of the toys and goes off on his new adventure with Bo Peep. Gets me every time.
The original Toy Story was the first movie I remember seeing in a theatre so maybe there's some nostalgia contributing to that.

The scene at the end of About Time between the father and son. I won't describe it, since I don't want to ruin it for anyone.

My obvious pick: "It's a terrible day for rain."
My niche pick: Patch Adams. The scene where he considers || jumping off the cliff ||
My IDGAF what you think pick: Avengers Endgame. "Hey, Pep" and "You can rest now."

The intro to the game stray

"It's not your fault" - Good Will Hunting

"A dog's purpose" movie's main purpose was to be tear jerker.

I remember Click (2006) being very sad, but I haven't watched it in a long time.
- Man that scene when he is screaming at himself while in auto pilot was brutal and gut wrenching
  The dad scene killed me
  
  I have become this dad. I think about these scenes often. It helps me remember and realign my priorities. I guess it's corny, but the message is valid and important.

The ending to that depressing as fuck Speilberg film A.I. Don't ever watch it unless you want to ruin your day.
- Man I had forgotten about A.i.
  Poor dude waited until the end of time to have his wish granted

ANY time any dog dies.
- 'Hachi: A Dog's Tale' killed me

Ibelin. Saw it in the cinema when it first came out, seemed like everybody in the audience was crying.
(It's about a kid with a degenerative disease who connected with people through an MMO.)

It's not a movie, it's an old avertisement, and I guarantee you if it doesn't stir something in you, you're not human:
https://youtu.be/OrvHe3xh6bM
- That crash was so cartoonish, I couldn't help but laugh at that.